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dc.contributor.authorALAS GUARDADO, SALOMON DE JESUS-
dc.coverage.spatial<dc:creator id="info:eu-repo/dai/mx/cvu/45957">SALOMON DE JESUS ALAS GUARDADO</dc:creator>-
dc.coverage.temporal<dc:subject>info:eu-repo/classification/cti/2</dc:subject>-
dc.date.issued2015-
dc.identifier.urihttp://ilitia.cua.uam.mx:8080/jspui/handle/123456789/23-
dc.description.abstractWe report a model for atomic force microscopy by means of computer simulations of molecular brushes on surfaces of biological interest such as normal and cancerous cervical epithelial cells. Our model predicts that the force needed to produce a given indentation on brushes that can move on the surface of the cell (called “liquid” brushes) is the same as that required for brushes whose ends are fixed on the cell’s surface (called “solid” brushes), as long as the tip of the microscope covers the entire area of the brush. Additionally, we find that cancerous cells are softer than normal ones, in agreement with various experiments. Moreover, soft brushes are found to display larger resistance to compression than stiff ones. This phenomenon is the consequence of the larger equilibrium length of the soft brushes and the cooperative association of solvent molecules trapped within the brushes, which leads to an increase in the osmotic pressure. Our results show that a careful characterization of the brushes on epithelial cells is indispensable when determining the mechanical response of cancerous cells.en_US
dc.language.isoInglésen_US
dc.publisherScientific Reportsen_US
dc.rightswww.nature.com/scientificreports-
dc.rights10.1038/srep13218-
dc.rightshttps://www.nature.com/articles/srep13218.pdf-
dc.subjectCélulas Cancerígenasen_US
dc.subjectCepillos Sólidos (Células)en_US
dc.subjectSimulación por Computadoraen_US
dc.titleComputer simulations of the mechanical response of brushes on the surface of cancerous epitelial cellsen_US
dc.typeArtículoen_US
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