Short constrained peptides derived from phage display libraries as epitope models : the case of mAb 2F5

Abstract

Since the monoclonal antibody 2F5 (mAb 2F5) was isolated in the early 90’s, its epitope have continued to be the focus of extensive investigations attempting to elucidate the mechanism by which impedes viral entry into host cells. Because the DKW-flanking amino acids are strongly conserved in viruses, it is not clear whether the DKW only satisfies the 2F5 epitope recognition demand.