| DC Field | Value | Language |
|---|
| dc.contributor.author | CASIQUE AGUIRRE, DIANA | - |
| dc.contributor.author | BRISEÑO DIAZ, PAOLA | - |
| dc.contributor.author | GARCIA GUTIERREZ, PONCIANO | - |
| dc.contributor.author | GONZALEZ DE LA ROSA, CLAUDIA HAYDEE | - |
| dc.contributor.author | QUINTERO BARCEINAS, REYNA SARA | - |
| dc.contributor.author | ROJO DOMINGUEZ, ARTURO | - |
| dc.contributor.author | VERGARA BAHENA, IRENE | - |
| dc.contributor.author | MEDINA VELAZQUEZ, LUIS ALBERTO | - |
| dc.contributor.author | CORREA BASURTO, JOSE | - |
| dc.contributor.author | BELLO RAMIREZ, MARTINIANO | - |
| dc.contributor.author | HERNANDEZ RIVAS, ROSAURA | - |
| dc.contributor.author | THOMPSON BONILLA, MARIA DEL ROCIO | - |
| dc.contributor.author | VARGAS MEJIA, MIGUEL ANGEL | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/332098">DIANA CASIQUE AGUIRRE</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/706648">PAOLA BRISEÑO DIAZ</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/176761">PONCIANO GARCIA GUTIERREZ,</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/40114">CLAUDIA HAYDEE GONZALEZ DE LA ROSA</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/420046">REYNA SARA QUINTERO BARCEINAS</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/10058">ARTURO ROJO DOMINGUEZ</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/253960">IRENE VERGARA BAHENA</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/121831">LUIS ALBERTO MEDINA VELAZQUEZ</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/201084">JOSE CORREA BASURTO</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/162262">MARTINIANO BELLO RAMIREZ</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/12705">ROSAURA HERNANDEZ RIVAS</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/263365">MARIA DEL ROCIO THOMPSON BONILLA</dc:creator> | - |
| dc.coverage.spatial | <dc:creator id="info:eu-repo/dai/mx/cvu/33773">MIGUEL ANGEL VARGAS MEJIA</dc:creator> | - |
| dc.coverage.temporal | <dc:subject>info:eu-repo/classification/cti/2</dc:subject> | - |
| dc.date.accessioned | 2021-07-29T21:58:45Z | - |
| dc.date.available | 2021-07-29T21:58:45Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | BMC cancer, 18(1), 2018 | en_US |
| dc.identifier.uri | http://ilitia.cua.uam.mx:8080/jspui/handle/123456789/915 | - |
| dc.description.abstract | The GTPase KRas4B has been utilized as a principal target in the development of anticancer drugs. PDE6δ transports KRas4B to the plasma membrane, where it is released to activate various signaling pathways required for the initiation and maintenance of cancer. Therefore, identifying new small molecules that prevent activation of this GTPase by stabilizing the KRas4B-PDE6δ molecular complex is a practical strategy to fight against cancer. | en_US |
| dc.description.sponsorship | BMC | en_US |
| dc.language.iso | Inglés | en_US |
| dc.publisher | Reino Unido : BMC | en_US |
| dc.relation.haspart | 1471-2407 | - |
| dc.rights | https://doi.org/10.1186/s12885-018-5142-7 | - |
| dc.rights | https://link.springer.com/article/10.1186/s12885-018-5142-7 | - |
| dc.subject | Cáncer de páncreas | en_US |
| dc.subject | Inhibidores | en_US |
| dc.subject | Cribado virtual | en_US |
| dc.subject | KRas4B | en_US |
| dc.subject | KRas4BG12C | en_US |
| dc.subject | PDE6δ | en_US |
| dc.subject | PDAC | en_US |
| dc.title | KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer | en_US |
| dc.type | Artículo | en_US |
| Aparece en las colecciones: | Artículos
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